The Mechanisms of Vascular Thrombosis in Behcet’s Disease

Behcet’s disease is a systemic vasculitis of every kinds and sizes of vessels. The prevalence of vascular involvement in BD has been reported as up to % 51.5. Vascular involvement includes superficial thrombophlebitis, deep venous thrombosis, arterial thrombosis, aneurysms and pseudoaneurysms. The inflammation induced endothelial injury seems to be the main mechanism underlying vascular thrombosis in BD. However, because of higher prevalence of thrombosis in BD in comparison to other vasculitic disease, some other possible trombotic mechanisms have been suspected to take role in the pathogenesis of vascular thrombosis in Behcet’s disease; for this reason the roles of coagulant and anticoagulant factors, fibrin and fibrinolytic pathway, and of thrombocytes have been studied for many years. In recent years, there are some studies confirming an existence of protrombotic state due to alterations in platelet activity and changes in coagulation mechanisms like increased hypofibrinolysis, altered fibrinogen structure and impaired fibrinogen function. The possible roles of thrombophilic factors like the mutations in factor V, prothrombin and MTHFR genes seem to be not confirmed by recent studies. The studies performed on homocysteine, Lipoprotein (a) and antiphospholipid antibodies have been evaluated with a careful approach. Emel Koseoglu* Department of Neurology, Faculty of Medicine, University of Erciyes, Kayseri-Turkey *Corresponding author: Emel Koseoglu, Department of Neurology, Faculty of Medicine, University of Erciyes, Kayseri-Turkey, Email: [email protected] Published Date: September 30, 2016